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They complement each other well for thorough tissue support

In preclinical cell-based models, hCG is used to interrogate Leydig cell responsiveness, CYP enzyme induction kinetics, and receptor desensitisation and internalisation dynamics

[104] [105] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given

It may, in fact, be the signal that every other intervention is ultimately downstream of