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GHK-Cu also stimulates both collagen synthesis and matrix metalloproteinases that break collagen down, so unbalanced or excessive use could in principle disrupt extracellular-matrix homeostasis

FIGURE 8 There was a significant increase in Il1b transcript levels in the colon of DSS/vehicle-treated mice compared to UT mice on day 3, while there were no differences in the expression of Tnf and Il10 transcripts between the DSS/vehicle-treated mice and the UT mice (Figure 8C)

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