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The L5-S1 joint plays a vital role in transmitting the weight of the body via the sacrum and ilium downwards

Leave-one-out sensitivity analysis found consistent results with the main analysis, except for the outcome of acute kidney failure in which there was a significant reduction with GLP-1 RA vs controls after the exclusion of the AMPLITUDE-O (Effect of Efpeglenatide on Cardiovascular Outcomes) trial (Supplemental Figures 18 to 26)

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2), and suppression of tumor cell migration and invasion

Cells were authenticated by morphology and tested for mycoplasma contamination before experiments