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There are biochemical reasons that suggest an intramuscular (IM) injection delivers hydroxocobalamin to the bloodstream more rapidly and potentially more effectively than the subcutaneous (SC) route
Journal of Clinical Investigation 123(3):966-972
Unlike oral supplements, IV and injectable options bypass digestion
In both trials, weight reduction was assessed after 72 weeks of treatment (at least 52 weeks at maintenance dose)
Best practice is to prepare single-use aliquots before freezing to minimize freeze-thaw events per volume
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