semaglutide kaiser Family Foundation Semaglutide as a MASH Treatment:

In the present study, we: 1) assessed the functional role of endogenous VTA GLP-1 signaling in cocaine seeking using projection-specific chemogenetic approaches, 2) determined cell type-specific expression patterns of GLP-1Rs in the VTA using fluorescent in situ hybridization (FISH) and single nuclei RNA-sequencing (snRNA-seq) methods, and 3) used in vivo fiber photometry in freely moving transgenic rats to further our understanding of the cell type-specific mechanisms in the midbrain underlying the suppressive effects of a GLP-1R agonist on cocaine seeking

In these mice, administration of tamoxifen allows nuclear transport of the Cre-recombinase resulting in deletion of the loxP-flanked stop sequence and permanent expression of YFP (Figure 1)

This personalized strategy often produces faster results with fewer side effects

14, 2023 Semaglutide and Cardiovascular Outcomes in Patients Without Diabetes A Michael Lincoff, et

Clinical trials are underway to try to confirm these benefits