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The ongoing phase 3 TRIUMPH trials are evaluating retatrutide across several key populations, including: Adults with obesity (BMI 30 kg/m, or 27 kg/m with weight-related comorbidities) Adults with type 2 diabetes Patients with cardiovascular risk factors the inclusion of a dedicated cardiovascular outcomes component is subject to confirmation via registered trial records

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reported similar improvements in cardiovascular outcomes across the three drug classes.61,62 However, it must be noted that selection bias could be prominent in observational studies, as the number of patients included in the study was significantly higher for those receiving DPP-4 inhibitors (28,898) than for SGLT2 inhibitors (5,677) or GLP-1 RAs (11,351).62 The lack of patients enrolled in specific groups also make the use of propensity score matching difficult

After recovery, there is another five-day course of treatment