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DECLARATIONS Authors contributions Conceived the design of this article and wrote the first draft

70 In addition, a clinical trial in 20 individuals with tinnitus found supplementing with CoQ10 (300 mg per day of ubiquinone formulated with ethyl alcohol and lecithin) for 12 weeks led to reductions in scores on a tinnitus questionnaire in a subset of participants whose blood CoQ10 levels were low at the beginning of the trial

Sample size calculation in animal studies using resource equation approach

Along the same line, accumulating evidence is drastically scaling back the supposed role of ACE2 upregulation by renin-angiotensin inhibitors in COVID-19 severity (Danser et al., 2020) which, according to some Authors view, might even be beneficial (Verdecchia et al., 2020)

Animal studies Numerous research studies have been carried out in animal models (murine and farm animals) to investigate how LC and ALC improve female reproductive functions [16, 19, 21, 42,43,44] (Table 1)