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GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others

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Melanotan or MT2 peptides are unregulated peptides administered as self-injections or through nasal sprays to create a tan without sun or UV exposure

severe nonproliferative DR includes intraretinal hemorrhages, venous beading, and moderate or prominent intraretinal microvascular abnormalities

Thyroid concerns: Animal studies identified thyroid C-cell tumours with some GLP-1 receptor agonists