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A few hours earlier, President Donald Trump announced a deal to significantly lower the out-of-pocket cost of GLP-1 drugs, in the range of $50 to $350 a month
Heres what the clinical data shows: Most Common: Nausea (affecting 15-44% of users), diarrhea (10-30%), vomiting (7-25%), and constipation (6-24%) Severity: 98.1% of gastrointestinal side effects are mild or moderate, with 99.5% being non-serious Duration: Median duration is 8 days for nausea, 3 days for diarrhea, and 2 days for vomiting Timing: Most side effects occur during initial weeks and dose escalation, declining over time Discontinuation: Only 4.3-10% of users discontinue therapy due to side effects Serious Events: Rare, with no increased risk of pancreatitis or malignancy in clinical trials Management: Slow dose titration, dietary modifications, and hydration significantly reduce symptoms Important Note: Weight loss is NOT caused by side effects
Chronic inflammation degrades the extracellular matrix, disrupts collagen architecture, and impairs the skin barrier function
59 Although multiple clinical trials have indicated high dietary soy isoflavone intake decreases the overall risk of breast cancer, 60 the possible protective effect of isoflavone supplements on breast cancer risk may be limited to estrogen receptor-expressing (ER+) tumors and women in perimenopause or early postmenopasue
Theres a big footnote for this trial that takes us back to the Bhaumik award and why there was such a long time before the realization the GLP-1 drugs could be useful for obesitypeople with diabetes on GLP-1 drugs didnt lose much weight
