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In bone, GIP may be a critical factor linking meal intake and bone formation [4] while GLP-1 has no direct effect on bone metabolism and inhibits bone resorption indirectly through upregulation of calcitonin [13]

For additional context on the FDA warning letter, the NYT profile, and the full scope of what was and wasn't referenced in the public record, the following resource covers that ground in detail: Content and Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice, diagnosis, or treatment

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Losing muscle around your hips, knees, spine, and shoulders leaves those areas more vulnerable to instability and mechanical overload, increasing the risk for: Tendinopathies Low back pain Knee osteoarthritis Rotator cuff injuries 2

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