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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

The latter cluster contained exclusively 5A-1MQ-treated animals switched from WD to LD (the WD/LD-T group), representing ~ 60% of all WD/LD-T animals

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Weight loss care may include medication, lifestyle changes, nutrition support, physical activity, and ongoing guidance from a healthcare provider