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While the mediation analysis indicated the treatment effect on SBP reduction were mainly through the weight loss, the results of the two analyses are not contradictory

30 This randomized, double-blind, placebo-controlled trial involved 478 participants, of whom 379 met criteria for non-responsiveness to prior treatments and received medication

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This triad is composed of three amino acids: Serine (Ser), Aspartic acid (Asp), and Histidine (His)