Malonyl-CoA synthesis is inhibited, either therapeutically or through the action of leptin resulting in activation of CPT1, thereby increasing mitochondrial import and fatty acid oxidation in muscle
And they show there's this really classical pain study
In addition to increased physical activity and a reduced-calorie diet, semaglutide prefilled pens and tablets are Adults with obesity[5](a body mass index (BMI) of 30 and higher) Adults who are overweight[5](a BMI of 27 and higher) with a weight-related health condition (examples include diabetes, high blood pressure, and high cholesterol) Children who are 12 years and older with obesity[1](a BMI in the 95th percentile for their age and gender assigned at birth) While BMI is a factor in determining if semaglutide is appropriate for weight loss, medical providers also use comprehensive professional judgement
Medscapes coverage of the FDAs concerns makes this line clear, and providers who cross it do so without the protections that govern standard clinical practice
This is partly metabolic, as the body adjusts to new hormonal signaling, and partly caloric, as reduced food intake means less available energy