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What 5 mg Tirzepatide Does Across the obesity trials, 5 mg per week is already a remarkably effective dose: Mean weight loss at 72 weeks of 15% from baseline body weight, compared with 3% on placebo Roughly 85% of people lose at least 5% of body weight at 5 mg, versus 35% on placebo HbA1c reduction in diabetes trials of about 1.9 percentage points from baseline at 5 mg A 31 to 52% rate of reaching HbA1c below 5.7%, the prediabetes-to-normal threshold Compared head-to-head with semaglutide 1 mg (the standard dose for the comparator drug at the time), tirzepatide 5 mg led to 1.9 kg more weight loss and a 0.15-percentage-point greater HbA1c reduction in a Phase 3 trial of 1,879 patients

Or BMI of 27 or higher with one of these: High blood pressure High cholesterol Sleep problems Heart problems Type 2 diabetes or prediabetes Must have tried to lose weight before without success

GLP-1 receptor agonist medications are designed to activate GLP-1 receptors in the body, helping many patients feel fuller sooner and stay full longer

Some patients tolerate one medication better than the other