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As the field evolves, its crucial for healthcare leaders and organizations to stay agile, adapt to new trends, and focus on what matters most for patients and providers, namely: GLP1s are now firstline therapies: Adoption has accelerated from just 3% in 2021 to more than 23% in 2025, displacing longstanding generics like metformin
Medical necessity The medication must be medically necessary for the treatment to be eligible for the Novo Nordisk PAP
HFD) for 16 weeks
44 Subsequently, there have been postmarketing reports of severe cases of joint pain in patients receiving DPP-4 inhibitor therapy
Dopamine reuptake inhibition: Increases dopamine in reward pathways Reduces food cravings and hedonic eating Enhances motivation and energy Similar to stimulant medications Creates euphoric feelings (can lead to dependency) 2
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