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Yu, J., Zhang, N

Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020

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Overall, we can see the value of targeting the GSH system in myocardial injury

Inhibition of 5-LOX in a Cell-Free Assay The enzyme activity of human recombinant 5-LOX was determined spectrophotometrically by monitoring the oxidation of H 2 DCFDA to the highly fluorescent 2,7-dichlorofluorescein during the catalytic reaction mediated by 5-LOX as reported ( Inhibition of LTA 4 H in a Cell-Free Assay Leukotriene A4 hydrolase activity was measured by monitoring the formation of LTB 4 with an enzyme-linked immunosorbent assay