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432 A 2021 systematic review and meta-analysis that included 22 observational studies with a total of 440,281 elderly participants with atrial fibrillation taking rivaroxaban, dabigatran, apixaban, or edoxaban found these medications were associated with similar reductions in risks of stroke and other embolic events, but rivaroxaban was associated with more bleeding events than apixaban or edoxaban

Meta-analyses indicate that GLP-1RAs generally reduce HOMA-IR and improve fasting blood glucose and 2 h OGTT levels in the PCOS population (78)

This is a complex system of microbes in the colon that help (or hinder) digestion and perform other functions

doi: 10.1104/pp.105.067223 29 LiY.BaldaufS.LimE

Beyond glycemic effects, GLP-1 receptor agonists slow gastric emptying, which prolongs the sensation of fullness after meals and contributes to reduced caloric intake