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The highest doses of Lillys and Novos pills also led to 8.2% and 5.3% weight loss, respectively

Notes: Higher doses compensate for reduced nasal bioavailability compared to injection

This is characterised by a hollow and sunken appearance on the cheeks and temples as well as accelerated signs of ageing such as loose skin and wrinkles

Retatrutide adds glucagon receptor activation for potentially greater fat loss Clinical trials show retatrutide achieving 24.2% weight loss at 48 weeks vs tirzepatide's 20.9% at 72 weeks Tirzepatide (Mounjaro/Zepbound) is FDA-approved and available now

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