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Incretin action of GIP is dramatically reduced in the presence of diabetes, as demonstrated by the evidence that glucose-dependent insulin secretion is not potentiated by GIP administration in subjects with diabetes [33, 34]

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Copper complexes are also photosensitive, and light exposure can drive both ligand oxidation and metal-centered photochemistry, so amber containers and dark storage are ordinary practice

In March 2026, the TRANSCEND-T2D-1 trial showed retatrutide delivered up to 2.0% A1C reduction and nearly 17% weight loss at 40 weeks with no plateau observed, meaning participants were still losing weight at the end of the trial