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Dose reduction, slower titration schedules, or temporary pauses allow the nervous system to acclimate
5-Ethynyl-2-deoxyuridine (EdU) incorporation assay DNA synthesis was assayed using the BeyoClick EdU Cell Proliferation Kit (Beyotime) according to the manufacturers instructions
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and regulation of gene expression via interaction with transcription factors such as STAT3 and Nrf2 24
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