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Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors
Meng X, Pang H, Sun F, Jin X, Wang B, Yao K, Yao L, Wang L, Hu Z
We demonstrated that in GLUTag cells, a high glucose level with L-glutamine stimulates GLP-1 secretion through a synergistic effect rather than cAMP amplification, and that a high glucose level potentiates L-glutamine-Gs activation in GLP-1 secretion
Pregnancy and breastfeeding GLP-1 medications should be discontinued before attempting pregnancy
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