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After 68 weeks of semaglutide 2.4 mg weekly, participants lost an average of 15% of body weight compared to 2.4% with placebo

This often manifests as slight changes in stubborn fat areas, increased definition in certain areas, or measurable changes on body composition assessments

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437,438 This involves modulating the cell apoptosis process, for example, by decreasing the Bax/Bcl-2 ratio in cardiomyocytes, reducing cytochrome C release, and caspase activation