Cells that have undergone ferroptosis remain at their normal nuclear size, without showing a lack of chromatin condensation, nuclear fragmentation, membrane blebbing, or formation of small vesicles known as apoptotic bodies, which are the signature morphological changes in apoptosis (Dixon et al., 2012
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Their approach includes validated sterilization, comprehensive sterility testing, and controlled manufacturing environments
SOURCES: Eli Lilly, statements, Aug
Additional Phase 3 readouts are expected through 2026 and 2027