Safety-wise, intramuscular B12 is generally well tolerated
Materials You Will Need Before beginning reconstitution of either BPC-157 or TB-500, ensure you have: Lyophilized peptide vial (verify identity, lot number, and purity certificate prior to opening) Appropriate solvent (see solvent selection section below) Sterile 1 mL or 3 mL syringe with a low-dead-volume tip Sterile needle (typically 23-25 gauge for vial penetration) Alcohol swabs A laminar flow hood or biosafety cabinet for sterile preparation Aliquot vials (low-binding microcentrifuge tubes or glass vials) if preparing multiple aliquots Labeling materials: lot number, concentration, date of reconstitution, initials Solvent Selection: BPC-157 vs TB-500 BPC-157 Solvent Options BPC-157 is highly water-soluble and reconstitutes readily in aqueous solvents
And it's not clear how well your body can absorb whole peptides from supplements, as they are usually completely broken down into amino acids in your digestive system
A 2020 review on the safety of BPC-157 in preclinical (animal) studies states that the peptide did not show any test-related effects in the single-dose toxicity study and that it was well tolerated in repeat-dose evaluations.16 Other animal studies and reviews mention that BPC-157 has no reported toxicity or that it was without a lethal dose in toxicology studies.14 17 Even the authors of a small human study on BPC-157 for interstitial cystitis note that no one dropped out of the study, and no adverse events were reported.18 We want to highlight that most of the relevant studies have been conducted on animals, and more human research is needed
How long does it take for BPC-157 to work