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Patients with a history of pancreatitis require careful consideration before starting semaglutide

For normal constipation, the recommendation is to see a doctor if the symptoms last longer than three weeks, if they make it difficult to perform daily activities, if there is blood involved in any way, or if you have stomach pain that refuses to go away

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Some providers may consider brief dose reduction followed by return to full dose as a receptor resensitization strategy, though evidence for this approach remains limited