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Before using any over-the-counter remedies including antiemetics, antidiarrhoeals, antacids, or herbal products always consult your trial team first, as some products may interact with the trial medicine or affect assessments

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Some clinical trials are open only to patients who have not started treatment

Participants were asked not to wear contact lenses two days prior to the study visit, and no fluorescein, anesthetic, dilating or other ophthalmic drops were applied before sample collection

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript