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Beyond the specific concern about diabetic retinopathy progression, broader research into GLP-1 receptor agonists and ocular health has been limited but generally reassuring
For comparison, tirzepatide (Mounjaro, Zepbound) has a slightly lower constipation rate at 14-17% across doses, possibly because the GIP receptor component partially counteracts GLP-1's motility effects in some patients
Scirica, a professor of medicine at Harvard Medical School, said the findings were "surprising." "The fact that semaglutide reduced non-cardiovascular death, and in particular COVID-19-related deaths, was surprising
However, it is specifically expressed in the cells of gastrointestinal (GI) tissue and thus is also known as GI-GPx [1, 8, 9]
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