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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)
Dev Biol 178(1):179185
the receptors are also found on tissues throughout the body, including the lungs, kidneys, nervous system, cardiovascular system, gastrointestinal tract, skin, and vagus nerve
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