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Biochemistry 30 , 74777483 (1991)

Research Focus : Safety & Metabolism (Non-Clinical) Title : Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health (J Endocrinol Metab, Vol 4, No 3, June 2014) Authors : Margret I

Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals

Additionally, selenium supplementation increased the risk of one type of skin cancer (squamous cell carcinoma) by 25%