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Propofol has been shown to not produce significant cognitive changes, to have a shorter recovery period compared with midazolam, and to have a better safety and efficacy profile.106108 Importantly, in endovenous sedation, lorazepam and oxazepam can be used with caution, if a benzodiazepine is needed to manage generalized anxiety disorder or sleep disorders, given that they are metabolized in the liver, mainly in biotransformation phase II

Safety data collection was limited to serious adverse events (including death), adverse events leading to discontinuation, and adverse events of special interest

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