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FASN inhibitors enhance bestatin-related tumor cell apoptosis through upregulating PEPT1

Neurons of the ventral midbrain that synthesize and release dopamine may be particularly susceptible to aging and have been described as biomarkers of aging whose functional decrements may reflect a core mechanism of aging itself (Rollo, 2009)

Chronic high-dose use (over 200 mg/day) may cause sensory neuropathy, usually reversible upon discontinuation

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