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doi: 10.1016/j.eprac.2023.11.002 68 OliveiraKJChiamoleraMIGiannoccoGPazos-MouraCCOrtiga-CarvalhoTM

These erectile function studies have established MT-II as the prototype centrally acting pro-erectile melanocortin agonist and provided the mechanistic framework for understanding how central MC4R activation produces peripheral erectile responses

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72 Drugs targeting gut microbiome changes Although the composition of gut microbiome varies among individuals, the prevailing bacterial phyla are Firmicutes and Bacteroidetes , that make up around 90% of the microbiome, and Actinobacteria and Proteobacteria