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The addition of a melanocortin agonist could accelerate or worsen pigmentary changes in patients already prone to them
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Conclusion 4-5: The lack of validated mechanistic biomarkers, beyond amyloid and tau, that can confirm that a pathway has been engaged by an intervention is compounded by the lack of markers that can act as a surrogate endpoint for assessing the efficacy of an intervention and limit the capacity of clinical trials to rapidly evaluate interventions
These structures are under daily stress and need regular regeneration which requires nutrients like sulfur
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