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In conclusion, on the basis of these studies, this review speculated that there may be two mechanisms of ferroptosis leading to obesity: (i) In the autonomic nervous system, vagus and parasympathetic nerves in some organs or tissues may be affected by ferroptosis and become dysfunctional, while the inflammatory factors released from adipocytes lead to excessive sympathetic activation and hypothalamic neuronal ferroptosis which promotes the development of obesity through a series of processes
We found that intraperitoneal injection of 100 g/kgbw of semaglutide every other day significantly improved the abnormal weight gain induced by a high-fat diet, reduced the proportion of white adipose tissue in the groin and epididymis
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