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The enzymes that constitute the de novo thymidylate pathway include cytosolic serinehydroxymethyl transferase (cSHMT), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR)

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While multiple previous studies have confirmed the association between the C4A gene and an increased risk of schizophrenia (132), the intrinsic mechanism underlying the negative correlation between C4B and schizophrenia risk remains unclear

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