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They found only one small exploratory ulcerative-colitis study with too little detail for firm conclusions, no clinical studies in Crohn's disease, and continuing concerns about product quality and safety

The mean increase in delta activity reached approximately 35% in the neocortex and limbic cortex compared to control animals receiving cerebrospinal fluid or other peptide preparations

Cautions: Limited human safety data means Dihexa carries more uncertainty than well-studied peptides

503A pharmacies using USP-grade ingredients from FDA-registered facilities