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The 33-amino acid peptide includes an Aib substitution at position 2 for DPP-4 resistance and a C20 fatty diacid at lysine-20 for albumin binding and once-weekly pharmacokinetics
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In general, GLP-1 and glucagon are believed to antagonize their respective effects on glucose homeostasis
Thyroid C-cell tumor warning: Thyroid tumor risk with some GLP-1 medicines
(2) Biodegradable materials: Choosing biodegradable substances that can be safely metabolized and removed from the body can help minimize the risk of lasting toxicity and tissue accumulation [339]
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