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The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation

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Although MPs alone does not induce PEV, in combination with Cd, PEV is enhanced

In accordance with the elevated hepatic GSSG/GSH ratio in HFD-fed mice, HFD consumption markedly increased hepatic 4-hydroxynonenal formation (Fig