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The Sun1/2-Nesprin-2 LINC complex is required for actin patch formation Cells depleted of Sun1/2 or Nesprin-2 by siRNA, or transfected with dnKASH, but not cells expressing KASH-L lacking the luminal SUN protein-binding KASH domain (Luxton et al, 2010), exhibited reduced actin patches at the base of the intercellular canal and increased frequency of broken chromatin bridges in cytokinesis compared with controls (Fig

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European Journal of Clinical Nutrition, 76 (2), 297-308

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Scientific Reports 12:484