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[8] Human pregnancy registries and population-based case-control studies demonstrate a dose-related elevation in the prevalence of cleft lip with or without cleft palate among infants exposed to topiramate monotherapy in the first trimester

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Systemic Primary Carnitine Deficiency is a metabolic disorder caused by mutations in the SLC22A5 gene [1] [11]

For most older adults with obesity, type 2 diabetes, or cardiovascular disease , the benefits are substantial but the potential risks must also be considered: Benefits: cardiovascular protection , significant weight loss , improved glucose control , blood pressure , and inflammation , with a lower risk of hypoglycemia compared to many older therapies

Interaction with insulin or oral diabetes medications may cause a significant drop in blood sugar levels