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PMID 26710256

Management Initial Treatment * Aggressive IV fluids (usually crystalloids) * Adequate analgesia (often opioids) * Oxygen if required * Antiemetics * Monitor urine output and vital signs Nutritional Support * Early enteral feeding preferred * Nasogastric or nasojejunal feeding if unable to tolerate oral intake Treat Underlying Cause * Gallstones: ERCP if cholangitis or persistent obstruction * Alcohol cessation counseling * Control triglycerides if elevated Antibiotics * Not routinely indicated * Reserved for infected pancreatic necrosis or confirmed infection Complications Local * Pancreatic pseudocyst * Pancreatic necrosis * Abscess * Hemorrhage Systemic * Shock * Acute respiratory distress syndrome (ARDS) * Acute kidney injury * Sepsis * Multi-organ failure * Gallstones and alcohol account for most cases

The results of proliferation assays indicated that HCC and PCa cells treated with siGGCT drastically inhibited cell proliferation compared with the control groups (Fig

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