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While his colleagues in the aging field overwhelmingly stick to a safe script, describing their research as a quest to extend years of health, Sinclair talks freely and excitedly about extending mortality to 150 years by the end of the centuryto say nothing of death eventually becoming a rarityboth of which critics say there is zero science to support

TLR4 (toll-like receptor 4) is a pattern recognition receptor protein that activates more inflammatory pathways ( NF-kB ) when it is activated by cell damage or by a pathogen

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GLP-1RA can also affect the process of skin aging through interaction with advanced glycation end products (AGEs) and RAGE (receptors of AGEs) activation

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