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Research Disclaimer: Doses reported below are from published preclinical research protocols

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Pharmacological inhibition of either Src or ERK for just 15 min resulted in rapid decline in -tubulin recruitment and microtubule nucleation when cells were adhered by wild-type integrins [17, 25], whereas molecular genetic approaches that resulted in the constitutive activation of Src or ERK restored the recruitment of -tubulin to the centrosome, as well as microtubule nucleation in cells adhered by mutant integrins [17, 25]

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