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The STEP 4 trial showed participants regaining approximately two-thirds of lost weight within one year of stopping medication
These patients reduced their initial weight by 5% through a low-calorie diet during the 4-12 weeks pre-trial induction period
J Clin Invest (2004) 113(11):157181
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Exclusion criteria included experimental studies, animal studies, and review articles
In heterozygous Akita mice (AK), this process aggravates proinsulin misfolding and results in the aggregation of wild-type proinsulin, which manifests as a progressive type-1 diabetes, termed type-1b diabetes [35]
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