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While early results are promising, clinical data for BPC-157 are limited

BPC-157 upregulates VEGFR2 expression and promotes receptor internalization, triggering downstream phosphorylation of Akt at specific sites (Ser473 and Thr308)

human clinical trials have not been completed.4-6,10

These receptors sit in the area postrema and the nucleus of the solitary tract, regions that regulate satiety, gastric emptying, and food intake

If oral bioavailability is low (1030%, similar to some quaternary ammonium compounds), a much higher oral dose would be required to match the plasma exposure achieved with subcutaneous injection