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Future research is expected to shed more light into the potential benefits and uses of this NNMT inhibitor

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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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This study was supported by the Genome Tagging Project and grants from the National Natural Science Foundation of China (32488101, 32370909, 32293231, 32470632, 32030029, and 92253302), the National Key R&D Program of China (2024YFA1800010), the CAS Strategic Priority Research Program B (XDB0990000), the Shanghai Municipal Science and Technology Major Project (23HC1401000), the National Science and Technology Innovation 2030 Major Project of China (2023ZD0500502 and 2021ZD0203900), and by the Medical Research Council of the UK (MR/T003162/1 to I.C.)