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Advances in Experimental Medicine and Biology, 1307 , 171192

Key Features Dual-mechanism design: GHRH-receptor agonism (CJC-1295) + GHSR agonism (Ipamorelin) for complementary GH-axis interrogation 99% Purity (HPLC/MS verified): Consistent material for reproducible protocols Protocol-friendly kinetics: Short, high-amplitude GH pulse (Ipamorelin) alongside prolonged GH/IGF-1 support (CJC-1295) in model systems GMP-compliant manufacturing (USA): Batch-to-batch reliability COA included: Full lot documentation Specifications Identity: CJC-1295 NO DAC /Ipamorelin USA cGMP Produced Form & Sizes: 10 mg or 20 mg blended vials Appearance: White to off-white lyophilized powder Purity: 99% (HPLC/MS verified) Manufacturing: GMP-compliant facility, USA Storage: 20 C, desiccated

All covariates listed in supplemental table 3 were included in the propensity score models, except for the laboratory test results, which were only available for a subset of patients

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