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We used an inducible model that with administration of tamoxifen allowed us to temporally delete the IGF1R after Nestin + cells in the brain had reached the quiescent phase but at a time point in which the skeleton continues to undergo rapid growth

However, studies in ZDF rats have also shown that metformin does not reduce cardiac fibrosis [120]

Rev ., 1 , 315-371

ClinicalTrials.gov NCT07625202 Momma H, et al

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