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SURMOUNT-1 Trial Tirzepatide Once Weekly for the Treatment of Obesity (NEJM, 2022) 5

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[57] Pharmacology [edit] Receptors as drug target [edit] Drugs that act as allosteric modulators of GABA receptors (known as GABA analogues or GABAergic drugs), or increase the available amount of GABA, typically have relaxing, anti-anxiety, and anti-convulsive effects (with equivalent efficacy to lamotrigine based on studies of mice)

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(Mounjaro)

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In short, they found that while consumers, employers and physicians are optimistic about the effectiveness of GLP-1s to treat obesity, cost and coverage are significant hurdles for consumer access

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