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Therefore, we evaluated the effect of the GLP-1R agonist, liraglutide, on cell GLP-1 production and PC1/3 expression using a tamoxifen-inducible cellspecific GLP-1RKO mouse model (9, 25)

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Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)

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